What is it?
How to read this profile
1Andarine-specific evidence and SARM-class findings are separated below. The evidence grade describes the limited human evidence for this compound; it does not turn animal or analytical studies into consumer benefits.
Check identity before comparing listings
8S-4 and Andarine identify the same research compound. A name on a retailer label is not independent confirmation of its contents; analytical identification in one internet product does not verify other batches.
Human class evidence is indirect
13A trial in 76 healthy men studied LGD-4033, a different SARM, for 21 days. It found hormone and HDL cholesterol suppression, with no drug-related serious adverse events; measured changes returned to baseline during follow-up. These findings support a class concern but cannot establish Andarine safety or recovery.
Evidence versus performance marketing
7Preclinical androgen-receptor activity and analytical detection do not show that Andarine improves cognition, strength or endurance in healthy users.
Andarine dosage evidence
5The reviewed sources do not establish an adult Andarine dose. Capsule strength and online cycle amounts describe products or practices, not a validated dosing protocol.
Names, aliases and forms
Mechanisms of action
What selective androgen receptor modulation means
7Androgen receptors respond to hormones such as testosterone. Preclinical SARM research aims for different activity across tissues. Tissue selectivity does not mean absence of hormonal effects or demonstrate a human benefit.
Potential effects and evidence map
Andarine-specific evidence is mainly preclinical pharmacology and analytical detection. Human studies of other SARMs provide indirect safety context, not Andarine efficacy or dose estimates. Cognitive benefit and healthy-adult safety at a defined dose and duration are not established.
Preclinical androgen-receptor research does not establish a human performance benefit for Andarine.
Timing & effect horizon
Reliable human Andarine onset, The time for blood levels to fall by half during the final elimination phase.Source, effect duration and safe cycle length were not established in the reviewed evidence. A study duration for another SARM cannot supply these missing values.
Safety, side effects and risk profile
Under the 2026 WADA rules, Andarine is prohibited at all times in governed sport.
Serious liver injury is reported with SARM products; the Andarine-specific incidence is unknown.
Androgen-related concern is inferred from Andarine pharmacology and human findings with other SARMs.
The U.S. FDA warns of potential heart attack and stroke with SARM bodybuilding products.
Pregnancy and lactation safety is not established; FDA SARM warnings include reproductive harms.
A 2017 analysis found substantial label/content discrepancies in internet products marketed as SARMs.
Sport Integrity Australia's Andarine advisory lists eyesight and altered colour perception among SARM-associated harms. It is not a controlled Andarine safety trial, and does not establish frequency, dose threshold or reversibility. Specific yellow-tint and night-vision claims are not quantified here.
FDA describes liver injuries requiring hospitalization in people taking SARM products. This class/product signal cannot quantify risk from pure Andarine at a defined dose.
The provisional hormonal concern is supported indirectly by the LGD-4033 trial, not a controlled Andarine trial. Pregnancy, lactation, adolescence and fertility-related contexts require separate caution; healthy adult male class data cannot establish safety in these groups.
The FDA identifies potential heart attack and stroke risks with SARM products. No Andarine-specific incidence estimate is available from that warning.
Legal and regulatory status
As of 15 October 2026, the U.S. FDA says SARM bodybuilding products are unapproved drugs, not dietary supplements, and warns against purchasing them. This is U.S. regulatory context; other jurisdictions and product categories may differ.
The 2026 WADA Prohibited List names Andarine among SARMs in S1.2, prohibited at all times in WADA-governed sport. Sport eligibility rules are distinct from national sale, possession and import rules.
Practical buying and quality notes
- A 2017 laboratory analysis of internet products marketed as SARMs found substantial discrepancies between labels and contents. This supports checking independent, batch-matched identity and content testing; it does not show that every current Andarine listing is mislabeled.10
- Check whether a price is per package, capsule or milligram, and verify the package count and stated strength before comparing. Duplicate records and inconsistent prices can distort a ranking. A cheap listing does not demonstrate quality.10
- A certificate of analysis describes the tested sample and methods. Check its batch identifier, laboratory and coverage of identity, amount and impurities. Even an accurate result cannot establish clinical safety or legal consumer use.10
FAQ
What does the label strength tell me?
10It is a stated amount per capsule or serving. It does not establish an evidence-based adult Andarine dose, and product-testing research shows why label accuracy matters.
Does a shorter cycle establish safety?
5No reliable Andarine duration threshold is established by the reviewed sources. Shorter exposure and breaks cannot be assumed to eliminate hormonal, eyesight or other concerns.
Does moderate mean safe?
5No. Moderate 3/5 is a provisional editorial estimate with low confidence, not a measured harm probability or endorsement. The uncertainty includes dose, duration, interaction effects and recovery.
References
- National Center for Advancing Translational Sciences. Inxight Drugs: ANDARINE.
- U.S. Food and Drug Administration. Certain Bodybuilding Products Put Consumers at Risk of Heart Attack, Stroke, Serious Liver Damage, and More.
- Operation Supplement Safety. SARMs.
- World Anti-Doping Agency. The 2026 Prohibited List: International Standard.
- Sport Integrity Australia. Don't risk using Andarine.
- Hoofnagle JH. Selective Androgen Receptor Modulators. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Updated 2025 Sep 20.
- Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003;304(3):1334-1340.
- Thevis M, Geyer H, Kamber M, Schanzer W. Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product. Drug Test Anal. 2009;1(8):387-392.
- Starcevic B, Ahrens BD, Butch AW. Detection of the selective androgen receptor modulator S-4 (Andarine) in a doping control sample. Drug Test Anal. 2013;5(5):377-379.
- Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017;318(20):2004-2010.
- Leciejewska N, Jedrejko K, Gomez-Renaud VM, Manriquez-Nunez J, Muszynska B, Pokrywka A. Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases. Eur J Clin Pharmacol. 2024;80(2):185-202.
- Vignali JD, Pak KC, Beverley HR, DeLuca JP, Downs JW, Kress AT, et al. Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users. J Xenobiot. 2023;13(2):218-236.
- Basaria S, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013;68(1):87-95.