Nootropics Index - Save on smarter supplements
Nootropics>Other / accessories & uncategorized>Tenoten
Other / accessories & uncategorized

Tenoten

Tenoten ultra-diluted anti-S100 antibody product

Tenoten is a product-specific ultra-diluted antibody preparation marketed in some jurisdictions, not a conventional nutrient, botanical, or standard nootropic compound. The claimed identity is antibodies to brain-specific S100/S100B protein in a highly diluted form. Public nootropic confidence is very low: the large adult anxiety trial indexed in PubMed is marked retracted, and the remaining literature is mostly product-specific, pediatric or condition-specific, animal, mechanistic, or manufacturer-adjacent. Do not use a Tenoten listing to infer an effect, product identity, current local regulatory classification, or individual suitability.

SerotonergicPatented IngredientBranded IngredientLimited Human EvidenceMixed EvidenceMostly Animal EvidenceInsufficient Evidence
Updated August 2026/6 min read/10 citations
Reviewed by the NootropicsIndex editorial team.Method: prioritize cited human research and official safety or regulatory sources; compare retailer-listed prices without endorsing products.Affiliate disclosure
01

What is it?

A product-specific ultra-diluted antibody preparation

4

Tenoten is not a conventional vitamin, mineral, botanical extract, amino acid, or small molecule. PubMed-indexed Tenoten literature describes it as a preparation based on antibodies to brain-specific S100/S100B protein, often in an ultralow-dose or highly diluted form. That makes product identity and jurisdiction more important than ordinary ingredient comparisons.

The key adult trial is retracted3
A large adult Tenoten anxiety randomized trial is indexed in PubMed as a retracted publication, with a linked Scientific Reports retraction note. That paper should not be counted as reliable positive evidence when evaluating Tenoten for calm, stress, or nootropic use.
02

Names, aliases and forms

Brand NameTenoten
Active ConstituentsAntibodies to brain-specific S100 protein; Anti-S100 antibodies
Research CodeNCT03036293
Spelling VariantTenoten for children
Chemical NameS100B protein antibody preparation
Regulatory NameHomeopathic / ultra-diluted antibody product
03

Mechanisms of action

Mechanism claims are not conventional pharmacology

6

Manufacturer-adjacent literature discusses highly diluted biologics and anti-S100 mechanisms, including serotonin-system animal work. These hypotheses do not establish a conventional dose-response, pharmacokinetic profile, or reliable human nootropic effect.

Animal and cellular findings stay preclinical

9

Animal and cellular studies of ultralow-dose anti-S100 antibodies report effects in experimental cognitive or emotional models. Those findings do not answer whether a consumer Tenoten listing improves cognition, focus, calm, or stress response in healthy adults.

04

Potential effects and evidence map

Tenoten has a weak and unreliable nootropic evidence base. PubMed includes a large adult anxiety randomized trial, but it is tagged as a retracted publication with a linked Scientific Reports retraction note. Other reports include Russian-language or product-specific clinical studies, pediatric studies, animal models, and mechanistic work on highly diluted biologics or ultralow-dose antibodies. This evidence does not establish Tenoten as a reliable cognition, calm, mood, or stress supplement.

Effect domainMagnitudeGrade
Focus / attention4
UnknownConfidence: High

No reliable adult nootropic evidence supports Tenoten as a focus or attention enhancer.

Note Available cognitive claims are product-specific, condition-specific, or low-confidence.

0/5
E
Memory / learning9
UnknownConfidence: High

Tenoten should not be presented as a validated memory or learning supplement for healthy adults.

Note Animal and pediatric/condition-specific reports do not establish adult supplement efficacy.

0/5
E
Calm / relaxation3
UnknownConfidence: Medium

Adult calm/anxiety-response evidence is unreliable because the large adult RCT is retracted and remaining evidence is not strong enough for supplement claims.

Note Clinical anxiety language should remain evidence-quality focused and not promotional.

0/5
E
Stress resilience1
UnknownConfidence: Medium

No reliable evidence establishes Tenoten as a stress-resilience nootropic for general users.

Note Do not infer healthy-user stress effects from condition-specific or retracted studies.

0/5
E
05

Typical dosages and timing

Dose context1Not established

ClinicalTrials.gov lists product-specific tablet regimens in NCT03036293, but the linked adult publication is retracted. Those trial schedules are not a public nootropic dose and do not translate to other products, countries, or formulations.

06

Timing & effect horizon

Effect horizonUnknown
Unknown
Onset, duration and cycle length are not established1

Tenoten does not have a reliable public-facing onset, duration, half-life, or cycle-length value for nootropic use. A 12-week registry schedule is a trial design, not an effect-duration or cycle recommendation.

07

Safety, side effects and risk profile

Do not substitute it for appropriate care3
The main practical safety issue is not a well-quantified toxicity signal; it is the risk of relying on weak or retracted evidence for anxiety, neurologic, pediatric, or cognitive concerns. People with symptoms that need care should not use Tenoten listings as a substitute for qualified medical assessment.
Evidence uncertainty3
Confidence: High

The main risk is acting on unreliable efficacy claims, especially because a large adult RCT is retracted.

Note Evidence uncertainty is the dominant public-page warning.

4/5
E
Legal / regulatory risk10
Confidence: High

Tenoten status depends on jurisdiction and product category; U.S. homeopathic products are not FDA-approved for safety or effectiveness, and cross-border listings can create import/label risk.

Note Keep U.S. FDA wording scoped to homeopathic products marketed in the United States; do not infer global status from one listing.

3/5
D
Interaction risk1
Confidence: Low

Do not use Tenoten as a substitute for clinician-directed care or combine it into neurologic/psychiatric regimens without professional review.

Note This is mainly a care-substitution and unknown-context risk, not a known pharmacokinetic interaction.

2/5
E
Pregnancy / lactation caution10
Confidence: Medium

Avoid Tenoten during pregnancy or lactation unless a qualified clinician has reviewed the exact product and jurisdictional context.

Note Pregnancy/lactation safety is not established for consumer nootropic use.

3/5
E
Review first5Insufficient public evidence

Pregnancy, lactation, and child use require professional review of the exact product, country, label, and indication. Pediatric studies do not make adult consumer use safer, and adult listings do not establish pediatric suitability.

08

Legal and regulatory status

United States - FDA homeopathic-products context, as of August 202610

FDA states that homeopathic products marketed in the United States are not FDA-approved for safety or effectiveness. That is a U.S. homeopathic-products statement, not a global rule for every Tenoten listing. Other jurisdictions may classify Tenoten as a medicine, homeopathic product, or unavailable/import-restricted product.

09

Practical buying and quality notes

  • Before comparing prices, check whether the listing is adult Tenoten, a pediatric formulation, a local-market medicine, a homeopathic product, or a cross-border reseller listing. The name alone does not establish legality, formulation, or suitability.1
  • For Tenoten, price per tablet is less important than whether the product identity, label language, jurisdiction, and evidence status are clear. The retracted adult RCT is a major reason to avoid promotional efficacy claims.3
10

FAQ

Is Tenoten a normal nootropic supplement?

4

No. Tenoten is a product-specific ultra-diluted anti-S100 antibody preparation. It should not be compared like caffeine, magnesium, L-theanine, or a standardized botanical extract.

Does Tenoten have reliable adult nootropic evidence?

3

No. The most visible adult randomized trial is retracted, and the remaining evidence is too product-specific, population-specific, preclinical, or low-confidence to support adult nootropic claims.

What Tenoten dose should users compare?

1

There is no reliable public nootropic dose. The ClinicalTrials.gov tablet schedules belong to a specific trial and product context, and the linked adult publication is retracted.

Is Tenoten FDA-approved in the United States?

10

Do not assume that. FDA states homeopathic products marketed in the United States are not FDA-approved for safety or effectiveness. Tenoten status should be checked for the exact country, product label, and seller.

Can Tenoten replace anxiety or neurologic care?

3

No. Tenoten should not be used as a substitute for qualified care, especially for anxiety, neurologic symptoms, pediatric concerns, pregnancy, lactation, or complex medication regimens.

11

References

  1. ClinicalTrials.gov. Tenoten in the Treatment of Somatoform, Stress-related and Other Neurotic Disorders. NCT03036293. Accessed 2026-06-30.
  2. Parfenov VA, Kamchatnov PR, Khasanova DR, et al. The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders. Scientific Reports. 2021;11:24282. Retracted publication.
  3. Parfenov VA, Kamchatnov PR, Khasanova DR, et al. Retraction Note: The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders. Scientific Reports. 2022;12:15416.
  4. Duma SA, Shishkin SV. Tenoten in the therapy of patients with moderate cognitive impairment. Bulletin of Experimental Biology and Medicine. 2009;148(2):311-314.
  5. Zavadenko NN, Skripchenko NV, Gaynetdinova DD, et al. Developmental disorders of academic skills in children: efficacy and safety of Tenoten for children in a multicenter double-blind placebo-controlled randomized study. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(9):128-136.
  6. Tarasov SA, Gorbunov EA, Don ES, et al. Insights into the Mechanism of Action of Highly Diluted Biologics. Journal of Immunology. 2020;205(5):1345-1354.
  7. Epstein OI, Beregovoy A, Sorokina NS, Starostina MV, Shtark MB, Gainutdinov KhL, Gainutdinova TKh, Muhamedshina DI. Membrane and synaptic effects of anti-S-100 are prevented by the same antibodies in low concentrations. Frontiers in Bioscience. 2003;8:a79-a84.
  8. Kheifets IA, Dugina YL, Voronina TA, Molodavkin GM, Martyushev-Poklad AV, Sergeeva SA, Epstein OI. Involvement of the serotoninergic system in the mechanism of action of ultralow dose antibodies to S-100 protein. Bulletin of Experimental Biology and Medicine. 2007;143(5):598-600.
  9. Voronina TA, Molodavkin GM, Borodavkina MV, Kheyfets IA, Dugina YL, Sergeeva SA, Epstein OI. Nootropic and antiamnestic effects of Tenoten pediatric formulation in immature rat pups. Bulletin of Experimental Biology and Medicine. 2009;148(3):524-526.
  10. U.S. Food and Drug Administration. Homeopathic Products. Accessed 2026-06-30.
Note

This page is informational and summarizes available evidence. It is not medical advice, a recommendation, or a substitute for guidance from a qualified clinician.